Alzheimer’s Disease

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    About Treatment

    Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of amyloid plaques and neurofibrillary tangles. Approved medications provide only symptomatic relief without affecting AD progression. Because of the multifactorial nature of AD and the absence of effective treatment, stem cell-based therapy has been regarded as an effective, safe, and innovative therapeutic approach to overcome AD. Different sources of stem cells are employed for AD treatment, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). There is a growing body of evidence supporting the promising therapeutic potential of stem cell transplantation, which might be attributed to the mechanistic actions exerted by stem cells such as inducing hippocampal neurogenesis, secreting paracrine factors, exerting anti-inflammatory activity, showing anti-amyloidogenic potential, and finally resulting in cognitive recovery. Although stem cell-based therapy faces potential hurdles, it holds a potential hope to provide a safe, effective, and feasible clinical application of stem cells in AD patients.

    Improvements

    Improvements that can be expected after stem cell therapy:

    Restoration of motor coordination

    Sleep normalization

    Emotional and mental state improvement

    Speech improvement

    Growth of neurons and new brain cells

    Cognitive function improvement

    Restoration of damaged organs and tissues

    Consultation from a doctor for free

    Get advice from a leading specialist and find out how stem cells will help you.

    Reviews

    Feedback on the condition of the patient with Alzheimer’s after the stem cell therapy

    Gender: F. Age: 64. Country: Norway
    Diagnosis: Alzheimer’s disease. Nodular polyosteoarthrosis of shoulder joints, small wrist joints with grade 0-I functional insufficiency of the joints.
    Dates of treatment: February 15-16, 2012

    Hello,
    Thanks for the email. A. has it very good after treatment, she has had great success in all areas. Her doctor tested her for two months and confirmed good results. The doctor was not aware of the treatment she received.The doctor was amazed at the progress.
    A. has good appetite, good mood, is more social and active as never before. She takes more initiative and likes to keep fit by cycling, skiing and daily walks. She forgets little now and then, but I do not think this has accelerated. We both believe that the treatment was of great benefit and are thankful for it and your professionalism.
    Sincerely,
    K. S. F.

    EmCell Clinic

    Neurodegenerative Diseases Stem Cell-based Therapeutic: A Perspective

    https://www.researchgate.net/publication/307609044_Neurodegenerative_Diseases_Stem_Cell-based_Therapeutic_A_Perspective

    The term neurodegeneration encompasses a broad range of diseases of central and peripheral nervous system. It’s only in less than 5% of the cases a clear genetic link has been established, however, majority is sporadic and driven by a combination of genetic and environmental factors. Alzheimer’s and Parkinson’s are the most common and renowned disorders that largely affect the elderly population. However, neural degeneration and associated loss of memory in these diseases is not a normal part of ageing as it occurs only in few, not all elderly people. It is considered that neurodegeneration is a generalized systemic disorder that also inflicts other organs, although it is most pervasive in neurons. Interestingly, it is not cell-autonomous, that means multiple cell types such as astrocytes, oligodendroglia, Schwann cells etc. are also involved. Thus investigating the cause of neurodegeneration at the cellular and sub-cellular levels is most challenging. Since initially only few cells are involved, it is impossible to access those cells in human and animal models. The post-mortem tissue although relevant but offer only retrospective indicator of disease. The current modalities are only symptomatic treatment with no cure in horizon. Therefore, therapeutic interventions for neurodegenerative diseases remain the most daunting task today. The emerging new technology like stem cells based therapeutics can offer some respite and is becoming an active area of research.

    Perspectives of stem cells use in alzheimer’s disease treatment

    https://www.researchgate.net/publication/325857008_Perspectives_of_stem_cells_use_in_alzheimer%27s_disease_treatment

    The article contains analysis of perspectives of cell technologies use in the therapy of patients with Alzheimer’s disease (AD). Currently there are no effective ways to diagnose this disease at early stage. Late diagnostics of AD and weak understanding of its mechanisms complicate clinical tactics leaving in fact palliative (symptomatic) treatment as the only available option. Authors propose a combination of the traditional methods of treatment with newly developed cell therapy technologies. Stem cells (SC) implantation is the basis for recovery of functional activity of neural networks in the regions affected by neurodegeneration. Based upon conducted experimental studies and analysis of scientific literature, the authors recommend to use the technique of the intranasal perineural application of autologous mesenchymal stem cells (MSC) for the treatment of patients with Alzheimer’s disease. Following the administration into the submucosa of nasal cavity, SC migrate along the olfactory nerve to the brain promoting a reparative effect, particularly attributed to the excretion of neurotrophic factors (brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), insulin growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF)). Keywords: alzheimer’s disease, cell technology, intranasal implantation, stem cell, therapy