Cardiovascular system diseases
Ensure the healthy future
Cardio function improvement
Regeneration of the damaged tissues after heart attacks
Improvement of blood supply to the heart
Reduction of fibrosis processes
Restoration of blood flow in large areas of the coronary arteries
Heart rate normalization
Stem Cell Therapy for Cardiovascular Disease
I’d like to give you an overall view of what is going on in stem cell therapy for cardiovascular disease. There are 2 major types of cells to consider (Fig. 1). One is skeletal myoblasts, which are already committed skeletal muscle cell precursors or satellite cells that are present in skeletal muscle. These cells can be harvested and, after 2 or 3 weeks of culture, implanted into (for example) an area of scar in the heart, for the purpose of muscle substitution. On the other side of the stem cell world are cells derived from the bone marrow or from other tissues. These include true stem cells in the sense that they may turn into a variety of tissues.
Cardiovascular disease constitutes the primary cause of mortality and morbidity worldwide, and represents a group of disorders associated with the loss of cardiac function. Despite considerable advances in the understanding of the pathologic mechanisms of the disease, the majority of the currently available therapies remain at best palliative, since the problem of cardiac tissue loss has not yet been addressed. Indeed, few therapeutic approaches offer direct tissue repair and regeneration, whereas the majority of treatment options aim to limit scar formation and adverse remodeling, while improving myocardial function. Of all the existing therapeutic approaches, the problem of cardiac tissue loss is addressed uniquely by heart transplantation. Nevertheless, alternative options, particularly stem cell therapy, has emerged as a novel and promising approach. This approach involves the transplantation of healthy and functional cells to promote the renewal of damaged cells and repair injured tissue. Bone marrow precursor cells were the first cell type used in clinical studies, and subsequently, preclinical and clinical investigations have been extended to the use of various populations of stem cells. This review addresses the present state of research as regards stem cell therapy for cardiovascular disease.