Developmental Delay

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About Treatment

Children do not grow and develop according to a timetable but there are conditions that shouldn’t be neglected. Developmental delay is more than just being a little behind children of the same age. Minor differences, like not rolling over by 4 months, shouldn’t cause concern. However, if the child is constantly behind kids of his age, it is a serious reason to see the doctor. There are various types of developmental delays in young children and infants, such as problems with cognitive skills, movement, speech or language, vision. Sometimes children have delays in many or all these areas. This condition is called “global development delay”. Statistically, 4% of children have delays in different areas of development.

There’s no universal treatment for all children with developmental delay as every case is unique in its causes and symptoms. Stem cell therapy is an innovative way to treat children with this disorder. For the treatment of developmental delay, doctors usually use the patient’s own stem cells. Implanted stem cells stimulate reparative processes in the brain, improve its nutrition and boost the immune system. As a result, children develop cognitive functions and skills needed for social adaptation. Stem cell therapy in complex with other methods of treatment, individually chosen for every child, shows impressive results. Regenerative therapy stimulates internal forces of the organism and work of neurons that results in the elimination of disease manifestation.

Improvements

Improvements that can be expected after stem cell therapy:

  • Speech and language skills improvement. Children gain the ability to use and understand language
  • Better skills of concentration
  • Motor skills improvement
  • Cognitive skills improvement. Older children are learning to count, new words, colors. Babies express curiosity
  • Social and emotional skills improvement. It implies emotions control, express of feelings and communication with others

Reviews

  • JACK

    Age: 14

    Country: UK

    Leukodystrophy. Cerebral Palsy. Global Developmental Delay

    We arrived to Infinity Clinic in hope to improve health of my boy, suffering from impaired development of the nervous system. His disease manifested with tetra paresis, low muscle tone in the upper extremities and left leg, high muscle tone in the right leg, splayfoot on the right, speech delay. He was unable to maintain vertical position. 6 months after the treatment with fetal stem cells in Infinity clinic his condition improved.  He show better capacity to move arms and hands (when he tries to hold the glass (with support), he now sometimes raises his elbow, that was not possible before; a little bit more strength in the arms and legs; nystagmus range reduction; seems to have more control of the neck; he tries to roll and sometimes manages; pronunciation and phrase structuring is a little better. I want to express my sincere gratitude to the doctors and founders of the Infinity Clinic!

    Infinity Clinic

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Shiroor, Divya & Bohr, Tisha & Adler, Carolyn. (2020). Injury Delays Stem Cell Apoptosis after Radiation in Planarians. Current Biology. 10.1016/j.cub.2020.03.054.

Stem cells are continuously exposed to multiple stresses, including radiation and tissue injury. As central drivers of tissue repair and regeneration, it is necessary to understand how their behavior is influenced by these stressors. Planarians have an abundant population of stem cells that are rapidly eliminated after radiation exposure via apoptosis. Low doses of radiation eliminate the majority of these stem cells, allowing a few to remain [1]. Here, we combine radiation with injury to define how stem cells respond to tissue damage. We find that a variety of injuries induced within a defined window of time surrounding radiation cause stem cells to outlast those in uninjured animals. Injury stimulates localized cell death adjacent to wounds [2], in the same regions where stem cells persist. This persistence occurs in the absence of proliferation. Instead, stem cells are retained near the wound due to delayed apoptosis, which we quantify by combining fluorescence-activated cell sorting (FACS) with annexin V staining. Pharmacological inhibition of the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (ERK) prevents stem cell persistence after injury, implicating wound-induced ERK activity in this response. By combining radiation with injury, our work reveals a novel connection between dying cells and stem cells that remain. Furthermore, the ability to induce stem cell persistence after radiation provides a paradigm to study mechanisms that may contribute to unanticipated consequences of injury, such as tumorigenesis.

Gertz, Marc & Lacy, M & Inwards, D & Gastineau, Dennis & Tefferi, A & Chen, M & Witzig, Thomas & Greipp, P & Litzow, M. (2000). Delayed stem cell transplantation for the management of relapsed or refractory multiple myeloma. Bone marrow transplantation. 26. 45-50. 10.1038/sj.bmt.1702445.

The optimal timing of stem cell transplantation for multiple myeloma is controversial. Late stem cell collection is undesirable because of the inability to mobilize stem cells. We report on 64 recipients of stem cells collected within 1 year after diagnosis, none of whom had transplantation in plateau phase of their disease. Patients seen within 12 months after diagnosis received four cycles of standard vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy and then had stem cells mobilized. Patients were then placed on maintenance vincristine, BCNU, melphalan, cyclophosphamide, and prednisone or melphalan and prednisone chemotherapy for 12 cycles. At the sign of first progression, transplantation occurred. Fourteen patients were refractory to VAD chemotherapy, 20 relapsed on maintenance chemotherapy, and 30 relapsed off chemotherapy. The time to platelet engraftment was not affected by the duration of stem cell cryopreservation or extent of chemotherapy exposure after mobilization. The complete response rate was 34%. The actuarial median survival from initial diagnosis, from transplant day 0, and post-transplant progression-free survival was 51, 20 and 11.4 months, respectively. The patient status at transplantation and percentage of plasma cells circulating in the blood at apheresis influenced post-transplant survival; circulating plasma cells, status at transplantation and plasma cell labeling index influenced progression-free survival. Response duration was shorter in patients relapsing on chemotherapy.

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