Diabetes mellitus type 1

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About Treatment

The use of stem cells in regenerative medicine holds great promise for the cure of many diseases, including type 1 diabetes mellitus (T1DM). Any potential stem-cell-based cure for T1DM should address the need for beta-cell replacement, as well as control of the autoimmune response to cells which express insulin. The ex vivo generation of beta cells suitable for transplantation to reconstitute a functional beta-cell mass has used pluripotent cells from diverse sources, as well as organ-specific facultative progenitor cells from the liver and the pancreas. The most effective protocols to date have produced cells that express insulin and have molecular characteristics that closely resemble bona fide insulin-secreting cells; however, these cells are often unresponsive to glucose, a characteristic that should be addressed in future protocols. The use of mesenchymal stromal cells or umbilical cord blood to modulate the immune response is already in clinical trials; however, definitive results are still pending.

Improvements

Improvements that can be expected after stem cell therapy:

Significant improvement in the functioning of the pancreas

Restoration of the damaged blood vessels

General improvement of health condition

Normalization of sugar level

Immune system stimulation

Decreasing or eliminating the need for sugar-reducing medication

Consultation from a doctor for free

Get advice from a leading specialist and find out how stem cells will help you.

The letter from J. Sch.-J. suffering from diabetes

Patient: J. Sch.-J.
Age: 49
Gender: Male
Diagnosis: Type I diabetes and diabetic neuropathy
Country: Denmark

The patient J. Sch.-J. with diabetes underwent stem cell treatment at EmCell clinic in autumn 2010. A month after the treatment, he wrote the following letter:

One day I googled the latest research on diabetes in Danish. I saw EmCell and the Danish site where it was possible to Contact Lotte Nielsen and hear her explanation about stem cells. Then I examined all available material on EmCell online. All this put together with Lotte’s explanation resulted in that I decided to choose EmCells treatment.

Before I came to Kiev, I had very severe pains in my legs and under my feet. They were so violent that I was aware that there had to be done something. Otherwise I could not work in my company much longer. The pain in my legs was so strong that I constantly was dead tired, no matter how much I slept.

EmCell’s staff acted very professionally. It is the most professional team I have ever been treated by and I have tried many treatments with my type 1 diabetes through 46 years.

Stem cell therapy started working already 10 minutes after the transplantation. The sharp pain began to subside in my legs….

EmCell Clinic

Stem Cell Therapy and Type 1 Diabetes Mellitus: Treatment Strategies and Future Perspectives

https://pubmed.ncbi.nlm.nih.gov/29896720/

Type 1 diabetes mellitus (T1DM) is classified as an autoimmune disease which progressively results in the depletion of insulin-secreting β-cells. Consequently, the insulin secretion stops leading to hyperglycemic situations within the body. Under severe conditions, it also causes multi-organ diabetes-associated dysfunctionalities notably hypercoagulability, neuropathy, nephropathy, retinopathy, and sometimes organ failures. The prevalence of this disease has been noticed about 3% that has highlighted the serious concerns for healthcare professionals around the globe. For the treatment of this disease, the cell therapy is considered as an important therapeutic approach for the replacement of damaged β-cells. However, the development of autoantibodies unfortunately reduces their effectiveness with the passage of time and finally with the recurrence of diabetes mellitus. The development of new techniques for extraction and transplantation of islets failed to support this approach due to the issues related to major surgery and lifelong dependence on immunosuppression. For T1DM, such cells are supposed to produce, store, and supply insulin to maintain glucose homeostasis. The urgent need of much-anticipated substitute for insulin-secreting β-cells directed the researchers to focus on stem cells (SCs) to produce insulin-secreting β-cells. For being more specific and targeted therapeutic approaches, SC-based strategies opened up the new horizons to cure T1DM. This cell-based therapy aimed to produce functional insulin-secreting β-cells to cure diabetes on forever basis. The intrinsic regenerative potential along with immunomodulatory abilities of SCs highlights the therapeutic potential of SC-based strategies. In this article, we have comprehensively highlighted the role of SCs to treat diabetes mellitus. Keywords: Autoimmune diseases; Diabetes mellitus; Pancreatic islets; Regenerative medicines; Stem cell therapy.

Stem Cell Therapy Emerging as the Key Player in Treating Type 1 Diabetes Mellitus

https://pubmed.ncbi.nlm.nih.gov/27424148/

Type 1 diabetes mellitus (T1DM) is an autoimmune disease causing progressive destruction of pancreatic β cells, ultimately resulting in loss of insulin secretion producing hyperglycemia usually affecting children. Replacement of damaged β cells by cell therapy can treat it. Currently available strategies are insulin replacement and islet/pancreas transplantation. Unfortunately these offer rescue for variable duration due to development of autoantibodies. For pancreas/islet transplantation a deceased donor is required and various shortfalls of treatment include quantum, cumbersome technique, immune rejection and limited availability of donors. Stem cell therapy with assistance of cellular reprogramming and β-cell regeneration can open up new therapeutic modalities. The present review describes the history and current knowledge of T1DM, evolution of cell therapies and different cellular therapies to cure this condition. Keywords: adult stem cells; induced pluripotent stem cells; insulin-secreting cells; mesenchymal stromal cells; stem cell therapy; type 1 diabetes mellitus.