Erectile Dysfunction Treatment
Ensure the healthy future
Erectile function restoration, increased penile rigidity
Reduced level of blood glucose and general improvement of blood values
Stimulation of the immune system
Normalization of the nervous system, improved mental state
Libido boost, sexual performance improvement
Stem cell therapy in diabetic men with erectile dysfunction: a step closer to safe and effective regenerative technology
I would like to congratulate the authors on an interesting paper exploring the clinical outcomes of bone marrow-derived mesenchymal stem cells (BM-MSC) injections in diabetic men with erectile dysfunction (ED) (1). This prospective pilot, open-label single arm study showed an improvement in penile erection following 2 separate intracavernous injections of BM-MSC given 30 days apart, with sustained effect up to 12 months as evident by the IIEF-5 and EHS scores.
Preclinical research into various animal models of ED has highlighted many pathophysiologic mechanisms contributing to ED such as cavernous nerve injury and diabetic models (2) and over the past decade, there has been considerable interest in stem cell (SC) therapy in the treatment of ED. The MSC is by far the most frequently used cell types in the field of urology and the most popular method of SC delivery in ED treatment is intracavernosal injection given its ease of administration and has proven success in both preclinical and clinical trials (3–5). The regenerative effects of SC are likely achieved by secretion of various growth factors into the blood stream and/or migration of these factors to major pelvic ganglia in addition to cell contact, paracrine signalling system and cellular differentiation (6,7)….
Erectile dysfunction (ED) is the most common sexual disorder that men report to healthcare providers, and is the male sexual dysfunction that has been most investigated. Current treatments for ED focus on relieving the symptoms of ED and therefore tend to provide a temporary solution rather than a cure or reversing the cause. Recently, therapies based on stem cells (SCs) have had an increasing attention for their potential to restore erectile function. Preclinical studies showed that these cells might reverse the pathophysiological changes leading to ED, rather than treating the symptoms of ED. This review is intended to provide an overview of contemporary reports on the use of SCs to treat ED.