Female and male infertility
Ensure the healthy future
Sperm count increase, significant improvement of semen quality
Improvement of nervous and endocrine systems functioning
Female fertility boost
Stimulation of the immune system
Normalization of the menstrual cycle
Activation of the ovarian function
Uterine function normalization
The association of female and male infertility with telomere length (Review)
Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres.
MESENCHYMAL STEM CELLS TREATMENT OF MALE INFERTILITY
The present study was conducted to investigate the ability of mice bone marrow mesenchymal stem cells to treat male infertility induced by cyclophosphamide injected in the caudal vein of albino male mice. The study was carried out on 30 albino male and 10 female mice obtained from Theodore Bilhariz Research Institute, Ministry of Scientific Research, Giza, Egypt. The mice were acclimatized then subdivided into three groups each contains 10 mice each with an average body weight 23-25 g ; group(1); normal control, Group (2) male infertility induced group with Cyclophosphamide untreated and group (3) male infertility induced group and treated with mesenchymal stem cell isolated from bone marrow blood. Male infertility induction takes by obtaining a loading dose 50 mg / kg at 24 h, then rotating dose 8 mg/kg for14 days constantly. Data obtained from the study showed that Seminiferous tubules of mouse testis were damaged in group (2) after male infertility induction by CTX. However follicle stimulating hormone (FSH) was significantly with high values in pc-ctx group observed after 36 days but increased with Slightly values in tscs group. In addition to testosterone obtained in two assay total and free, total testerone was decreasing with high values in pc-ctx group observed after 36 days but decreasing with slightly values in tscs group. However free testerone was decreasing with high values in pc-ctx group observed after 36 days but decreasing with slightly values in tscs group. In another side histological assay in pc-ctx group demonstrated that seminifrous tubes was damaged in spermatogonia and other germinal cells but in tscs was slight destruction. The results showed that after induction mice has been induced induction but repairing after stem cells treatment.