Metabolic syndrome

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    About Treatment

    Metabolic syndrome is an obesity-based, complicated clinical condition that has become a global epidemic problem with a high associated risk for cardiovascular disease and mortality. Dyslipidemia, hypertension, and diabetes or glucose dysmetabolism are the major factors constituting metabolic syndrome, and these factors are interrelated and share underlying pathophysiological mechanisms. Severe obesity predisposes individuals to metabolic syndrome, and recent data suggest that mesenchymal stem cells (MSCs) contribute significantly to adipocyte generation by increasing the number of adipocytes. Accordingly, an increasing number of studies have examined the potential roles of MSCs in managing obesity and metabolic syndrome. However, despite the growing bank of experimental and clinical data, the efficacy and the safety of MSCs in the clinical setting are still to be optimized. It is thus hoped that ongoing and future studies can elucidate the roles of MSCs in metabolic syndrome and lead to MSC-based therapeutic options for affected patients. This review discusses current understanding of the relationship between MSCs and metabolic syndrome and its potential implications for patient management.


    Improvements that can be expected after stem cell therapy:

    Metabolism is stabilized. Man lose weight.

    It is possible to avoid the development of cardiovascular disease and type 2 diabetes. With metabolic syndrome, there are risks of such diseases.

    A person can lead a more active lifestyle.

    Fatigue and apathy disappear.

    No shortness of breath, headache, night sweats and drowsiness after meat-eating.

    Consultation from a doctor for free

    Get advice from a leading specialist and find out how stem cells will help you.

    Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications

    … Mesenchymal stem cells are multipotent cells with the potential to differentiate into a variety of cell lineages including fat, bone, cartilage, muscle, and marrow stroma [4]. Although adipogenesis is a multistep process involving many cellular intermediates, for practical purposes it is currently characterized in two major phases: the determination phase and the terminal differentiation phase [1618]. The determination phase involves commitment of a pluripotent stem cell into the adipocyte lineage [1618]. In the terminal differentiation phase, the fibroblastic preadipocyte takes on characteristics of the spherical mature adipocyte, in that it can synthesize and transport lipids and secrete adipocyte-specific proteins, and it contains the machinery necessary for insulin sensitivity [1618].

    Stem cell therapy for obesity-induced metabolic disorders

    Stem cells have the potential to grow into other tissue types such as bone, cartilage and muscle, making them suitable for treating metabolic disorders such as diabetes, insulin resistance and high levels of blood lipids.

    A combination of high food intake and lack of physical activity increases fat storage in the body that puts stress on the metabolic pathways, eventually leading to metabolic dysfunction and disorders. Long-term use of drugs such as metformin, used to manage diabetes, cause adverse effects.

    In search of a safer alternative, scientists from the Manipal Academy of Higher Education and Jain University in Bangalore, India, prepared three different stem-cell-based formulations. They then injected separate groups of obese mice with the different formulations and compared their efficacy with that of metformin.

    All the formulations significantly lowered glucose and serum triglyceride levels in the mice. Besides, the formulations significantly reduced serum insulin levels. Of all the formulations, stem cell suspension remarkably reduced inflammation and triglycerides in the liver….