Multiple Sclerosis

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About Treatment

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS).

Improvements

Improvements that can be expected after stem cell therapy:

Strengthening the immune system. The cause of multiple sclerosis remains unknown. In the mechanisms of the development of the disease, the main role is played by the destruction of the myelin sheath of the nerves by the immune system. At the site of damage, connective tissue (sclerosis) is formed. As a result, the transmission of electrical impulses along the nerve is disrupted.

Disorders of sensitivity, speech, and vision disappear.

Muscle weakness, imbalance and coordination of movements disappear. Painful muscle tension (spasticity), trembling (tremor) remain in the past.

Chronic fatigue disappears.

Memory improves. Forgetfulness, difficulty with concentration of attention, as well as mood swings, depression disappear.

Consultation from a doctor for free

Get advice from a leading specialist and find out how stem cells will help you.

  • Deborah H.

    Age: 66

    Country: USA

    MULTIPLE SCLEROSIS

    As far as my symptoms are concerned, my cognitive deficits are greatly improved. My thinking is clearer and I remember things better now.  The weakness on my left side feels about 40% better as well as the numbness and tingling.  My balance and gait issues are greatly improved.  I can walk farther than before without my crutches.  I can stand without holding on to anything for much longer time than before.  I stand straight and walk better, faster and farther.  The incontinence has improved and the muscle spasms have lessened. My energy level has greatly improved. I haven’t been able to cook or clean for at least 10-12 years and now I can do those things again.  I am back working in the ceramic studio and I don’t get tired till the end of the day. The pain is almost all gone and the swallowing problem is much much better.  I still don’t have much sense of taste and the prolonged wound healing hasn’t changed and I no longer have the beginning of glaucoma!  My blood pressure has been normal for the past 4 months and my doctor says my reflexes are normal now. I am very pleased with my results even though the surgery might have hampered the improvement so I would  do it again. I thank you very much for giving me my life back!

    Infinity Clinic

Condition of the patient M.C. with multiple sclerosis

Patient: M.C.

Gender: Female
Age: 63
Country: USA

Diagnosis: Secondary progressive multiple sclerosis with cerebrospinal involvement, spastic paraparesis of lower extremities and urine retention.  EDSS – 4,5-5. Vertebrogenic dorsopathy with moderate pain

It has been 1 month since M. was treated at your clinic for Secondary Progressive Multiple Sclerosis. We will be sending additional updates on a monthly basis. So far, she has experienced the following improvements in her symptoms:

  1. She had 2 painful spots on her spine. Middle of spine spot is completely gone. Lower back spot is no longer painful. Only a moderate amount of pressure remains.
  2. Improved leg muscle strength. Has been able to stand up from a sitting position much easier and has been able to increase distance walking with walker.
  3. Increased energy level.
  4. Sleeping very well with 3mg. of Melatonin. We have eliminated Tylenol PM for sleeping.
  5. Bottom of feet remain less picky and painful. Feels like walking on smooth pebbles.
  6. Friends and neighbors have commented that M. looks more vibrant and interested in activities.
  7. A short time after treatment M. felt movement in her stomach area that lasted for about 3 days….

EmCell Clinic

The patient H. feedback after the second course of stem cell treatment

Patient: H.
Age: 42
Gender: Male
Diagnosis: Multiple sclerosis
Country: Germany

The patient underwent the first course of stem cell treatment in 2001. After the treatment, positive results were achieved, and the patient H. didn’t need top-ups for the next 8 years.

The second course of stem cell treatment was carried out in May 2009.

Right after return home, Mr. H. has noticed the following improvements:
“On May 9 I had my first instant success at home: from airport I travelled by car to my home. We live on the second floor. Without thinking about climbing stairs as usual (I need the handrail absolute) I arrived in my flat and was very happy that it was as easy as 12 years ago”.

Five months after the second course of embryonic stem cell treatment patient H. wrote the following:
Dear Sirs,
As you described before, at present, I find myself in the second phase of posttransplantation effects when the amount of stem cells has increased in the organs and systems. In this connection, I would like to ask Doctor Smikodub once again about the restoration of myelin he told me during our first conversation before the beginning of the treatment….

EmCell Clinic

New multiple sclerosis treatment trial compares stem cell transplantation to best available drugs

https://www.nih.gov/news-events/news-releases/new-multiple-sclerosis-treatment-trial-compares-stem-cell-transplantation-best-available-drugs

MS is an autoimmune disease in which a person’s own immune cells attack the central nervous system. The experimental treatment involves using a mixture of four chemical agents to remove these immune cells. Some of the person’s own blood-forming stem cells, which were extracted before treatment, are then infused back into the individual. These cells repopulate the immune system, allowing it to reset itself so that the new immune cells no longer attack the central nervous system. It is estimated that MS affects more than 2.3 million people worldwide, mostly women, including more than one million people in the United States. Symptoms of the disease vary widely and may include motor and speech difficulties, weakness, fatigue and chronic pain. The most common form of the disease is relapsing-remitting MS, which is characterized by periods of mild or no symptoms interspersed with symptom flare-ups, or relapses. Incomplete recovery from relapses often leads to increasing disability. Over years, the disease can worsen and shift to a progressive form that may also include relapses.

Stem Cell Therapy for Multiple Sclerosis

https://pubmed.ncbi.nlm.nih.gov/30039439/

Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system (CNS). It is characterized by demyelination and neuronal loss that is induced by attack of autoreactive T cells to the myelin sheath and endogenous remyelination failure, eventually leading to functional neurological disability. Although recent evidence suggests that MS relapses are induced by environmental and exogenous triggers such as viral infections in a genetic background, its very complex pathogenesis is not completely understood. Therefore, the efficiency of current immunosuppression-based therapies of MS is too low, and emerging disease-modifying immunomodulatory agents such as fingolimod and dimethyl fumarate cannot stop progressive neurodegenerative process. Thus, the cell replacement therapy approach that aims to overcome neuronal cell loss and remyelination failure and to increase endogenous myelin repair capacity is considered as an alternative treatment option. A wide variety of preclinical studies, using experimental autoimmune encephalomyelitis model of MS, have recently shown that grafted cells with different origins including mesenchymal stem cells (MSCs), neural precursor and stem cells, and induced-pluripotent stem cells have the ability to repair CNS lesions and to recover functional neurological deficits. The results of ongoing autologous hematopoietic stem cell therapy studies, with the advantage of peripheral administration to the patients, have suggested that cell replacement therapy is also a feasible option for immunomodulatory treatment of MS. In this chapter, we overview cell sources and applications of the stem cell therapy for treatment of MS. We also discuss challenges including those associated with administration route, immune responses to grafted cells, integration of these cells to existing neural circuits, and risk of tumor growth. Finally, future prospects of stem cell therapy for MS are addressed.