Parkinson’s disease (PD)

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About Treatment

Parkinson’s disease is one of the most severe and mysterious illnesses of modern times. It is a progressive chronic disease that usually affects older people. PD is a degenerative disorder of the central nervous system that results in tremor, loss of automatic movements, rigid muscles, problems with speech and writing, slowed movements and other symptoms. The exact cause of the disease is unknown; it can be caused by the mutation in genes or some environmental factors. Conservative methods of treatment can not cure PD and can only ease the symptoms.

The last breakthrough in treating Parkinson’s disease is stem cell therapy. Human embryonic stem cells have the potential to become any other cell in our body. Dopamine is a neurotransmitter that is needed for the regulation of movement and emotional responses.

People with PD experience loss of dopamine, as a result of which patients develop tremor and muscle rigidity. Researchers have proved that human embryonic cells can differentiate into dopamine cells and help people with Parkinson’s disease. There has also been a success with the use of embryonic stem cells that can “discover” damaged tissues and start the regeneration process. The type of stem cells used for the treatment and its results are individual. Doctors develop a plan for each patient based on clinical examination and analysis. The goal of stem cell therapy is to eliminate the cause of the disease and provide decent life for the people with PD.

Improvements

Improvements that can be expected after stem cell therapy:

Restoration of motor coordination

Elimination or reduction of tremors and rigidity

Sleep normalization

Emotional and mental state improvement

Speech improvement

Growth of neurons and new brain cells

Cognitive function improvement

Consultation from a doctor for free

Get advice from a leading specialist and find out how stem cells will help you.

Reviews

Report on improvements in patient H.R. suffering from Parkinson’s disease

Patient: H. R.

Gender: Female

Age: 69

Country: USA

Diagnosis: Akinetic-rigid and tremor-dominant Parkinson’s disease, stage II (Hoehn, Yahr).  Grade II-III left-sided scoliosis

Hi,

H. and I arrived home safely.
We are so thankful for you and Sergey.  Mom is doing much better. Her back pain has already reduced and her bowel function has much improved. Even 30 of those herbal drops did not clear her bowels the other day!  Mom is also smiling more frequently–a sure sign of a good immune system. She is walking more and feeling good.

I also feel good. I’m not tired after the long trip. One of the signs of my age have been that I get stomache ache or head ache when I don’t get enough sleep. I’m not getting that now. My bowel is also like that of a baby, every meal!!!

And to think, the stem cells haven’t even started working yet!

Thanks, We will be in touch….

EmCell Clinic

The letter from the wife of the patient with Parkinson’s disease after stem cell treatment

Patient: N.N.
Age: 62
Gender: Male
Diagnosis: Parkinson’s disease
Country: Russia

Pre-therapy condition: “Off” periods during the whole day. Marked difficulty in walking. Marked balance disturbances. Tremor in the right arm and leg. Severe stiffness in the right arm and leg muscles. Incontinence.

Patient N., suffering from Parkinson’s disease, was treated with stem cells at EmCell clinic. Immediately upon returning home he found positive changes in his condition as described below by his wife:

“Stem cells is a miracle”, N. exclaimed. “Weakness in my leg has almost disappeared. I can freely turn around, I quietly go sideways what I couldn’t do before! I could easily step over the suitcases; I am not awkward any more! Before the stem cell treatment, I had to watch my way and even couldn’t talk when walking, but on my way home after the stem cell treatment I could easily look about, and my balance was normal. I am not dragging my leg like I used to.”

I stopped my husband’s monologue and asked him to repeat it once again to write it down….

EmCell Clinic

Stem Cell Applications in Parkinson’s Disease

https://www.researchgate.net/publication/314979563_Stem_Cell_Applications_in_Parkinson%27s_Disease

Parkinson’s disease (PD), characterized by the loss of dopaminergic neurons in the substantia nigra, is one of the most common neurodegenerative disorders in elderly people. However, few effective therapies are available for neurodegenerative diseases, including PD. Stem cell therapies have been studied as potentially effective treatment options for neurodegenerative diseases through mechanisms of neuronal regeneration and substitution. Stem cells can migrate into injured regions and produce new neurons and glia, as well as neuroprotective molecules to improve neuron survival in the region. The survival and integration of these transplanted stem cells is an important issue for the success of stem cell therapy in neurodegenerative disease. Recent research in animals shows the promise of stem cell transplantation as a powerful treatment for Parkinson’s disease, among other neurodegenerative diseases, in the near future.

The Potential Role of Astrocytes in Parkinson’s Disease (PD)

https://www.researchgate.net/publication/338848365_The_Potential_Role_of_Astrocytes_in_Parkinson%27s_Disease_PD

Astrocytes are multi-functional cells, now recognized as critical participants in many brain functions. They play a critical physiological role in the clearance of neurotransmitters, such as glutamate and gamma-aminobutyric acid (GABA), and in the regulation of K+ from the space of synaptic clefts. Astrocytes also express the excitatory amino acid transporters (EAATs) and aquaporin-4 (AQP4) water channel, which are involved in both physiological functions and neurodegenerative diseases (ND). Some of the ND are the Alzheimer’s (AD), Huntington’s (HD), Parkinson’s diseases (PD), Cerebral edema, amyotrophic lateral sclerosis (ALS), and epilepsy pathological conditions in specific regions of the CNS. Parkinson’s disease is the second most common age-related neurodegenerative disorder, characterized by degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc). These project to the striatum, forming an important pathway within the basal ganglia. Mostly, PD has no clear etiology, and the mechanism of dopaminergic (DA) neuron loss is not well illustrated. The results of various studies suggest that astrocytes are involved in the pathophysiology of PD. Evidence has shown that the down-regulation of EAAT-2/GLT-1 and AQP4 expression is associated with PD pathogenesis. However, controversial results were reported in different experimental studies about the expression and function of EAAT-2/GLT-1 and AQP4, as well as their colocalization in different brain regions, and their involvement in PD development. Therefore, under neurological disorders, Parkinson’s disease is related to the genetic and phenotypic change of astrocytes’ biology. In this review, the authors summarized recent their research findings, which revealed the involvement of EAAT-2/GLT-1 and AQP4 expression, the physical interaction between EAAT-2/GLT-1 and AQP4 in astrocyte function, and their potential role in the development of PD in SNpc and Subthalamic nucleus (STN) of the basal ganglia nuclei.