Rehabilitation after stroke and neurological diseases
Ensure the healthy future
Speech recovery after a stroke.
Recovering memory after a stroke.
Recovery of motility and motor functions.
Restoration of vision.
Improving psycho-emotional activity.
The future of stem cell therapy for stroke rehabilitation
The biggest challenge is the coalescing cell therapy with rehabilitation therapy in an effort to realize improved outcomes in stroke patients. Indeed, in the recent Stem Cell Therapeutics as an Emerging Paradigm for Stroke or STEPS 3 meeting, a key theme that was advanced by the group is to examine stem cell therapy vis-à-vis with rehabilitation therapy to reveal not only stand-alone effects of each therapy [1, 2], but to potentially assess the concept of combination therapy for stroke. Although stroke rehabilitation is well recognized in the clinic , most of the preclinical studies on stem cell therapy have not incorporated this rehabilitation effect in the experimental design. Accordingly, this lack of rehabilitation control arm in the laboratory represents as a major disconnect between the preclinical arena and the clinical setting, limiting the recognition of the potential benefits of stem cell therapy to stroke rehabilitation and vice versa. Notwithstanding, if we define rehabilitation as ‘exercise’, there are excellent studies in the laboratory that have assessed the beneficial role of exercise in influencing the fate of endogenous stem cells. The concept that exercise enhances neurogenesis was popularized by Rusty Gage and colleagues . In particular, in this paper and several other subsequent papers from this group and others showed that new cells almost doubled in the hippocampus after just 12 days of daily running. A paper by Mark Mattson , fittingly titled ‘take away my food, and let me run’ discusses the benefit of running, as well as good diet!…
Stroke is an important cause of death in the world and disability worldwide especially in developed countries. It has two sub-types, hemorrhagic and ischemic and the latter make up the majority of all strokes, almost 80% of the total susceptibilities of neurons in the brain to injuries such as ischemia leading to difficult treatment of suffered patients from the involved diseases. Following acute phase of stroke, some procedures and medical treatment such as thrombolytic agents has been recommended; nevertheless many patients have enduring deficits. Thus, there is a realistic need to develop treatment strategies for reducing neurological deficits. On the other hand, in stroke, damage process is acute and restricted in time, also multiple cell types including, endothelial and neural cells has been lost therefore, the brain may be more ready to transplantation than in other neurologic diseases. However, the stem cell (SC) therapy could arrange an alternative intervention for disease modifying therapy.