Viral hepatitis B, C
Ensure the healthy future
For the patients after chemotherapy: stimulation of the immune system, reduction of antiviral agents toxicity, restoration of liver functions
For patients who are contraindicated in antiviral drugs: reduction of viral load, restoration of the liver structure and functions, protection of the vital body functions.
For patients with cirrhosis and hepatic failure: regeneration of cell structure and liver function, normalization of biochemical indicators, improvement of metabolism, reduction of bleeding risks, ascites, portal hypertension, a significant improvement in the quality of life.
Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research
Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. Here we summarize the use of human stem cell-derived hepatocyte-like cells for hepatotropic virus infection studies, including the dissection of virus-host interactions and virus-induced pathogenesis as well as the identification and validation of novel antiviral agents.
Hepatitis B virus (HBV) is a hepatotropic virus that can infect extrahepatic tissue. Whether hematopoietic stem cells (HSCs) can be infected by HBV and serve as a potential virus reservoir is still unknown. In this study, the susceptibility of CD34+ HSCs to HBV was investigated.
Above all, we demonstrated that HBV can replicate in CD34+ HSCs no matter where it is, in cord blood or peripheral blood of chronic HBV carriers. CD34+ HSCs might be another possible reservoir of HBV and a source of immune cells that play an important role in the pathogenesis of persistent HBV infection. Further studies are needed to demonstrate how HBV works in HSCs and its effects on the differentiation of HSCs.